Prednisone may increase your risk of harmful effects from a live vaccine. Live vaccines include measles, mumps, rubella (MMR), rotavirus, yellow fever, varicella (chickenpox), one type of the typhoid vaccine and nasal flu (influenza) vaccine. Find information about common, infrequent and rare side effects of Prednisone Oral. Prednisone is an oral steroid medication. If you have serious worsening of asthma symptoms (an asthma attack), your doctor may prescribe a brief course of oral steroids such as prednisone. Oral. No, but you will feel a lot better. Most of prednisone's serious side effects take months or years to develop. Along with its needed effects, prednisone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Corticosteroids carry a risk of side effects, some of which can cause serious health problems. When you know what side effects are possible, you can take steps to control their impact. Serious Prednisone Side Effects Long Term You are less likely to encounter the serious and long-term side effects of Prednisone. But if you do not take the aforementioned precautions, you should contact your doctor at the slightest indication of the Prednisone side-effects listed below: Serious side effects include reactions to diabetes drugs, infections, and necrosis of the hips and joints. Corticosteroids like prednisone, have many drug interactions ; examples include: estrogens , phenytoin ( Dilantin ), diuretics, warfarin ( Coumadin , Jantoven ), and diabetes drugs. Taking them concomitantly with Prednisone increases the risk of serious infections. Quinolone antibiotics (norfloxacin, ofloxacin, ciprofloxacin, levofloxacin, and moxifloxacin). Concomitant use of Prednisone and these drugs increase the risk of tendon rupture. Side effects of prednisone and other corticosteroids range from mild annoyances to serious, irreversible organ damage, and they occur more frequently with higher doses and more prolonged treatment.